Wellbutrin SR (bupropion SR): What You Need to Know

Wellbutrin SR is a sustained‑release form of bupropion used to treat depression and help with smoking cessation. It boosts dopamine and norepinephrine, which can lift mood and increase focus without the sexual side effects common with many SSRIs. People choose SR when they need twice‑daily dosing and steadier blood levels than immediate‑release formulas offer.

How it’s taken matters. Typical start is 150 mg once daily for three days, then 150 mg twice daily. Doctors usually cap SR at 400 mg per day; going higher raises the risk of seizures. Missed doses should not be doubled — take the next scheduled dose and talk with your prescriber if you miss many doses.

What to expect and common side effects

Many people feel brighter after 2–4 weeks, though full benefit can take 6–8 weeks. Common side effects include dry mouth, trouble sleeping, headache, and sweating. Unlike many antidepressants, Wellbutrin SR is less likely to cause weight gain or sexual dysfunction, but it may increase anxiety in some people.

Serious but rare problems include seizures and allergic reactions. Seizure risk rises with higher doses, a history of seizures, eating disorders like bulimia, heavy alcohol use, or certain drugs that lower the seizure threshold. If you have any of those risks, mention them before starting.

Drug interactions, safety tips, and alternatives

Wellbutrin SR shouldn’t be combined with monoamine oxidase inhibitors (MAOIs) or other bupropion products. It can interact with drugs that also lower seizure threshold and with strong CYP2B6 inhibitors or inducers. Tell your provider about all prescription meds, OTC drugs, and supplements. Don’t stop other antidepressants suddenly without guidance.

Thinking about cost or brand? Generic bupropion SR is widely available and usually cheaper than the Wellbutrin brand. Your pharmacist can explain prices and insurance coverage. If Wellbutrin SR doesn’t work or causes side effects, options include bupropion XL, SSRIs, SNRIs, atypical antidepressants, and non‑drug options like therapy or TMS. Our site has a guide that compares alternatives and real‑world pros and cons.

Quick tips: start low and rise slowly, avoid alcohol while adjusting, keep regular sleep, and report worsening mood or suicidal thoughts immediately. Regular check‑ins with your prescriber help catch issues early and adjust dose safely.

If you’re using Wellbutrin SR to quit smoking, the brand Zyban follows similar dosing and usually starts one to two weeks before quit day. People often notice reduced cravings within two weeks, but full benefit may take longer. For those switching from other antidepressants, prescribers may cross-taper over weeks to avoid withdrawal symptoms. Blood pressure can rise in some people, so check it after starting and during dose increases. Pregnant or breastfeeding people should discuss risks and benefits; bupropion is sometimes used in pregnancy but needs medical oversight. Keep a list of symptoms to report, like severe headache, vision changes, suicidal thoughts.

Questions about dosing, interactions, or switching? Talk with your doctor or pharmacist — they can tailor advice to your health history and meds. Wellbutrin SR can work well for many people when used carefully and monitored.